How did the geography of mesopotamia and surrounding lands open the region to invasion

It didn't because Mesopotamia was a peninsula

The investiture controversy began as a power struggle between pope gregory vii (1072–85) and henry iv, holy roman emperor (1056–1106).[2] a brief but significant struggle over investiture also occurred between henry i of england and pope paschal ii in the years 1103 to 1107, and the issue played a minor role in the struggles between church and state in france, as well.by undercutting the imperial power established by the salian emperors, the controversy led to nearly 50 years of civil war in germany, and the triumph of the great dukes and abbots. imperial power was finally re-established under the hohenstaufen dynasty. historian norman cantor:

Amath expression is a collection of one or more terms, which are separated by the signs ( + , - , x , / ).example :   8+b8+b  or  a−3a−3in algebra, an equation is a mathematical statement with two expressions where, each expression is separated by an equal (=) sign. variables can be present on both the sides of the equality (=) sign and we use letters to denote such variables.example 1:   x=4+2x=4+2  , [here, we can observe that the variable is present only on one side of the equation].example 2:   2x+3=x+42x+3=x+4  , [here, we can observe that the variables are present on both side of the equation].