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there's multiple reasons why the conquistadors were so successful in colonizing central america, and some of them are:

- they were seen as gods;

at the beginning, the spanish settlers were seen by the natives as gods, and this was mainly due to their white skin, and the way they came with their boats.

- possessed superior weaponry;

the spanish had gunpowder and guns, as well as cannons, while the natives did not had any fire weapons.

- made cleaver alliances;

they used the situation of tribes hating each other, so they made alliances with some of them which served them very well.

- brought diseases;

the native people were not immune to certain diseases the europeans brought with them, so they were dying from seeming harmless things for european standards.