Which line from the strange case of dr. jekyll and mr. hyde best characterizes dr. jekyll as ill?

he did not rise to meet his visitor, but held out a cold hand and bade him welcome in a changed voice.
the doctor shuddered. “they were crying it in the square,” he said. “i heard them in my dining-room.”
“utterson, i swear to god,” cried the doctor, “i swear to god i will never set eyes on him again . .”
he was busy, he was much in the open air, he did good; his face seemed to open and brighten . .