Which phrase has the most negative connotation? A flourishing trend , a prevalent trend , a rampant trend ?

Which is not covered under the common topic “relationship” a. causes and effects b. comparisons and contrasts c. contraries and contradictions d. antecedents and consequences

Could someone me with this question?

Atheater director has decided that an all-female cast will perform macbeth, which has both male and female characters. which feature of the play would change the most?