Which line best develop the central idea that the plague was almost impossible for elizabethans to survive?

“although there are no fewer than twenty-three medical treatises . . none of them will you.”
“but you have the advantage of knowing that a fleabite can convey the plague . .”
“also, plague is most frequently transferred between people in towns, and it dies down in winter . .”
“change your clothes and bedclothes regularly, and wash them thoroughly.”