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Chemistry, 03.12.2021 19:40 tae8002001
Sulfonylurea hypoglycemic agents can be synthesized by the reaction of the sodium salt of an appropriate substituted benzenesulfonamide with a carbamic ester. The reaction mechanism involves the following steps: An amine reacts with diethylcarbonate to yield tetrahedral intermediate 1; Tetrahedral intermediate 1 loses ethanol to form carbamic ester 2; The sodium benzenesulfonamide reacts with carbamic ester 2 to form tetrahedral intermediate 3; Tetrahedral intermediate 3 loses ethanol to form the sulfonylurea. For the above sulfonylurea, identify the appropriate substituted benzenesulfonamide and amine. Write out the mechanism on a separate sheet of paper, and then draw the structure of tetrahedral intermediate 1.
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