what substances play an important role in communication between cells in a multicellular organism by acting as a chemical message

The correct answer is - ligands such as hormones and neurotransmitters.

Explanation:

Communications between the cells of the unicellular organisms take place by the chemical signaling and the substances that help in sending chemical signals between cells are called ligands.

A ligand is a chemical molecule that binds with a specific molecule or a specific signaling receptor, a protein in or on the target cell. Hormones and neurotransmitters are the ligands that help in cell signaling and send chemical messages to the target sites.

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