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(2R)-chlorobutane can undergo nucleophilic substitution with NaBr. This reaction can proceed
through either an SN2- or an Syl-mechanism.
a) Draw the mechanism, including the stereochemistry, of this reaction, include
intermediate(s) if
present, when assuming the reaction proceeds through an SN2-mechanism.
b) Sketch the graphical course of this SN2-reaction with the change in energy as function of the
reaction coordinate.
c) Why would you prefer to avoid an SNl-mechanism when you aim to achieve an enantiomerically
pure product? Explain your answer using the intermediate of this mechanism.
d) Why would you prefer to avoid an Sn1-mechanism even in the case a racemic mixture would be
permitted?
Would appreciate if you could answer even if one question!
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(2R)-chlorobutane can undergo nucleophilic substitution with NaBr. This reaction can proceed
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