Which of the following statements about macroions, large polyelectrolyte molecules, are true?a. These large molecules can often interact tightly with other molecules of opposite net charge. b. Concentrations of salts that mimic the ionic strength of cells tend to keep macromolecules in solution. c. Maximum solubility is achieved when the solution containing such a molecule is near the pI for that molecule. d. At high pH, macromolecules often carry net negative charges and therefore repel each other.