If 16 grams of sugar, C12H22O11, are in a spoonful, how many molecules of sugar are in the spoonful?

2.82x10^22 molecules.

Explanation:

From Avogadro's hypothesis, we understood that 1 mole of any substance contains 6.02x10^23 molecules.

The above hypothesis implies that 1 mole of sugar, C12H22O11 also contains 6.02x10^23 molecules.

1 mole of C12H22O11 = (12x12) + (22x1) + (16x11) = 144 + 22 + 176 = 342g

Now, if 342g of C12H22O11 contains 6.02x10^23 molecules,

Therefore 16g of C12H22O11 will contain = (16x6.02x10^23)/342 = 2.82x10^22 molecules.

Therefore, 2.82x10^22 molecules of the sugar are in the spoon