Chemistry, 16.03.2020 21:56 battlemarshmell

In a particular enzyme, an alanine residue is located in a cleft where the substrate binds. A mutation that changes this residue to a glycine has little effect on activity; however, another mutation, which changes the alanine to a glutamate residue, leads to a complete loss of activity. Provide a brief explanation for these observations.

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In a particular enzyme, an alanine residue is located in a cleft where the substrate binds. A mutati...