What alteration to an hcn channel will reduce the transport of k+ in favor of na+ transport? hcn channels are permeable to both k+ and na+ ions.

Decreasing the diameter of the channel by removing aa's. Since Na+ is chemically similar to K+, one can assume the difference must be due to the size of the atom. The K+ ion is larger than the Na+ ion, so reducing the diameter of the channel can allow Na+ to enter while preventing K+ entry. This explains clearly and perfectly how reducing the diameter reduces the

transport of K+ in favor of Na+ transport.

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