In nucleophilic acyl substitution, in nucleophilic acyl substitution, loss of the leaving group is followed by rearrangement of the carbocation. protonation of the carbonyl is followed immediately by loss of the leaving group. ester hydrolysis is followed by deprotonation. an sn2 reaction occurs. addition to the carbonyl by a nucleophile is followed by loss of the leaving group.

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Radon-222 or rn-222 has a half-life of 3.82 days. to determine the fraction of an original sample of rn-222 that remains unchanged after 7.646 days, we calculate the amount of rn-222 remaining after 7.646 days and divide it with the original amount. using 1 gram as a basis and using half-life calculation methods, we can determine that  0.249 or 0.25  grams of rn-222 will remain, and thus the fraction remaining is 0.25 or 1/4.