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Chemistry, 26.11.2019 06:31 mimacapa

Mutations in genes encoding cell signaling proteins contribute to many cancers. for example, a chromosomal translocation fuses the bcr gene to the abl gene, leading to a constitutively active bcr–abl kinase and chronic myeloid leukemia (cml). cml is successfully treated with the drug imatinib (trade name gleevec), which mimics an abl kinase substrate and thus inhibits kinase activity. what normal cell molecule, and kinase substrate, does gleevec mimic?

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