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Chemistry, 23.10.2019 19:20 enrique710

What is the benefit of substrate channeling? the pdh active site forms in the hydrophobic core of the complex instead of a surface‑exposed region. reaction intermediates move to sequential active sites faster than the diffusion constant. every intermediate or product made by the pdh complex enters the citric acid cycle as a substrate. the pdh complex sequesters excess substrate to use at later time. intermediates of a multistep reaction sequence do not dissociate from the enzyme complex.

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