The transition state of an enzyme- catalysed reaction that converts a substrate to a product a) is a transient intermediate formed along the reaction coordinate of the reaction b) has higher free-energy than either the substrates or products c) is the most populated species along the reaction coordinate d) is increased in concentration because the enzyme binds tightly to it e) determines the velocity of the reaction select one: a. a, b, d and e b. a and c c. a only d. d and e e. a, b, c and e