Gpcr activate g proteins by reducing the strength of gdp binding, allowing gdp to disassociate and gtp, which is present at much higher concentrations, to bind. how do you suppose the activity of a g protein would be affected by a mutation that caused its affinity for gdp to be dramatically reduced without changing its affinity for gtp?

the correct answer would be b, when, queen, calder hall and london.

explanation:

we always capitalize words when a paragraph or sentence is starting, when an important name is used, when a place is being written, or simply when a noun is used, etc. so in this sentence, sentence is starting from 'when', so it will be written in capital letters. secondly, queen is considered to be an important person, so it will also be written in capital letter. next, the name of the town is mentioned, i-e calder hall, which will also be written in capital letters. in the last,   city name is being used, 'london', which will also be written in capital letters. so option b is the most appropriate one.

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