Normally, activity of the hypothalamic-pituitary-adrenal axis is regulated by a feedback loop that reduces the release of cortisol. what is the order of signaling by which this reduction takes place? a. hypothalamus to hippocampus to adrenal glands b. hippocampus to pituitary gland to adrenal glands c. hypothalamus to pituitary gland to adrenal glands d. hippocampus to hypothalamus to adrenal glands

The correct answer is c. ​hypothalamus to pituitary gland to adrenal glands.

When it comes to stress, hypothalamus-pituitary-adrenal axis (HPA) is responsible for stress response. Hypothalamus releases corticotropin-releasing hormone (CRH) which binds to its receptors on the anterior pituitary gland. As a result, adrenocorticotropic hormone (ACTH) is released and it stimulates the release of cortisol from the adrenal gland. At a certain levels of cortisol, this steroid hormone exerts negative feedback to the hypothalamic release of CRH.

Bis the correct answer.