How does a tumor metastasize (spread around the body) and grow tumors in other places in the body?

Cancer cells have little to no adhesins on their cell surfaces hence do not bind other cells to form proper tissues. They also have the ability to penetrate the walls of lymphatic or blood vessels.  This way they are able to move from one point in the body from where the tumor is, travel through the blood and lymph vessels to other regions to another to form secondary tumors.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

i thinking chemical change