What contributes most significantly to the kidney's high energy expenditure?

The Flat Ascending Limb of the Loop of Henle is penetrable to the chemical element NaCl (Sodium Chloride) which is not water. It causes tubular fluid throughout the descending limb in the body to the thick ascending limb of the body. It is impenetrable to water and urea without maybe perforable to Chlorine.

the organisms are not adapted to live in some communities or habitats.

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."