Due to the generally large genome size, multiple sites are employed to start replication in eukaryotic dna replication. both eukaryotic and prokaryotic dna replication have to deal with the the issues of telomeres and replicating the ends of chromosomes. eukaryotic dna has to associate with histones. only eukaryotic dna replication uses single stranded binding proteins to prevent the double helix from reforming during replication. prokaryotic dna replication does not need dna ligase because prokaryotes have a circular chromosome.

In 1959, doctors began using the powerful antibiotic methicillin to treat infections of staphylococcus aureus, but within two years, methicillin-resistant strains of s. aureus (mrsa) appeared. how did the resistant strains of s. aureus emerge? in 1959, doctors began using the powerful antibiotic methicillin to treat infections of staphylococcus aureus, but within two years, methicillin-resistant strains of s. aureus (mrsa) appeared. how did the resistant strains of s. aureus emerge? staphylococcus aureus bacteria that were able to synthesize cell walls using a protein that was not affected by methicillin survived the methicillin treatments and reproduced at higher rates than did other individuals. over time, these resistant individuals became increasingly common. in response to treatment of staphylococcus aureus infections with methicillin, some bacteria began to synthesize cell walls using a protein that was not affected by methicillin. these bacteria survived the methicillin treatments and reproduced at higher rates than did other individuals. over time, these resistant individuals became increasingly common. in response to treatment of staphylococcus aureus infections with methicillin, bacterial populations gradually began to synthesize cell walls using a protein that was not affected by methicillin.