Biology, 04.08.2019 03:30 bvargas786p7aa8y

Albinism in humans is caused by homozygosity for mutant recessive alleles of the tyr gene, which is located on chromosome 11. alkaptonuria in humans is caused by homozygosity for mutant recessive alleles of the hgd gene, which is located on chromosome 3. suppose that a man and a woman who are each heterozygous carriers of mutant recessive alleles of both the tyr and hgd genes have five children. what is the probability that at least one of their children will have albinsim and/or alkaptonuria?

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Exactly 989527/1048576, or approximately 94.37%
Since each trait is carried on a different chromosome, the two traits are independent of each other. Since both parents are heterozygous for the trait, each parent can contribute 1 of a possible 4 combinations of the alleles. So there are 16 possible offspring. I'll use "a", "A", "b", "B" to represent each allele and the possible children are aabb, aabB, aaBb, aaBB, aAbb, aAbB, aABb, aABB, Aabb, AabB, AaBb, AaBB, AAbb, AAbB, AABb, and AABB
Of the above 16 possibilities, there are 7 that are homozygous in an undesired traint and 9 that don't exhibit the undesired trait. So let's first calculate the probability of "what are the chances that all 5 children not exhibiting an undesired trait?" and then subtract that result from 1. So
1-(9/16)^5 = 1 - 59049/1048576 = 989527/1048576 which is approximately 0.943686485 = 94.3686485%
So the answer is exactly 989527/1048576, or approximately 94.37%

Answer from: Quest

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Answer from: Quest

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."