What effect does an insertion or deletion have on the protein that is being manufactured?

The insertion and deletion are types of DNA mutations. Insertion involves addition of one or more base pairs of nucleotide into a gene. During gene expression the information carried in the gene is converted into protein. In case of insertion mutation, the size of the protein formed is bigger than the protein formed by the normal gene. Contrary, deletion is type gene mutation where the one or more base pairs of nucleotide are removed from the gene. As a result, the size of the protein synthesized from the resulting gene will be smaller than that of the normal gene. In both cases the resulting proteins might lose their normal functions.    

The insertion or elimination of the protein can have serious effects, because it is probable that the incomplete protein does not carry out its function. Inserts are mutations in which additional base pairs are inserted into a new place in the DNA. The resulting protein possesses only a few different amino acids in the sequence corresponding to the insertion site in a gene that encodes a version of the protein without intein from which it derives and can change over time requires not only de novo synthesis of proteins, but also the elimination of proteins whose functions are no longer necessary.

Six amino acids have side chains that are polar but not charged. these are serine (ser), threonine (thr), cysteine (cys), asparagine (asn), glutamine (gln), and tyrosine (tyr). these amino acids are usually found at the surface of proteins, as discussed in the proteins 2 module.