The amount of energy needed for a reaction to occur is known as the

The minimum amount of energy required for a reaction to occur is known as the activation energy. It is the minimum amount of energy needed to activate atoms or molecules to a condition in which they can undergo chemical transformation.

The source of the activation energy needed to push reactions forward is typically heat energy from the surroundings.  Heat energy speeds up the motion of molecules , increasing the frequency and force with which they collide. It also moves atoms and  bonds  within the molecules slightly helping them reach their transition state.

osteogenesis imperfecta (oi) refers to a congenital ailment of bones. in the condition, the bones become brittle or fragile. this ailment is a general result of the defect or mutations in the genes (colia1 or colia2). this mutation results in imperfect collagen formation either in quantity or quality wise.  

there are eight kinds of oi defects, and each kind varies with certain distinctions in symptoms. the usual symptoms include frequent bone fractures, loss of hearing in infants, protruding eyes, discoloration of the white in the eyes, respiratory issues, loosening of the joints, short stature, and other symptoms.