In cystic fibrosis, blockage of the pancreatic duct by thick mucus will prevent the flow of pancreatic juice into the duodenum; this will directly cause in cystic fibrosis, blockage of the pancreatic duct by thick mucus will prevent the flow of pancreatic juice into the duodenum; this will directly cause backup of pancreatic juice into the liver via the bile duct hyposecretion of pancreatic hormones atrophy of the pancreatic acini decreased motility of the small intestine