Mastering biology why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?

answer; i believe the correct answer is (replication is not conservative);

the level of progesterone is low at the pre-ovulatory phase of the cycle but it gradually increases and the levels are high at the luteal phase. if pregnancy occurs, the level of progesterone will be high throughout the pregnancy.

if egg is fertilized and the mother gets pregnant, progesterone starts preparing the uterus for the implantation. it starts building up the lining of uterus and make it hostile of the period of pregnancy.