Why is it necessary to give the hpv vaccine in multiple doses? the hpv vaccine contains poorly immunogenic antigenic fragments. the hpv vaccine mimics the actual infection from hpv. the hpv vaccine does not replicate in the host. the hpv vaccine must be administered to multiple portals of entry to provide protection at each portal?

The answer to this question would be: the HPV vaccine does not replicate in the host

Administering a vaccine will induce the body immune cells to recognize it and produce a specific antibody for that antigen. The vaccine can be beneficial if the titer of the antibody is above a certain level. If the level of antibody is too low, the protection will be low too. Giving vaccine multiple time will increase the titer and increase the protection. HPV vaccine is safe because it won't replicate in the host so it can be administered multiple times.