Which type of mutation plays the most important role in increasing the number of genes in the gene pool?
A. Changes in nucleotide sequence that lead to natural selection removing the allele from the population
B. Point mutation with a change in one base resulting in a harmful phenotype
C. Rearrangement of gene loci due to deleting or disrupting chromosomes
D. Gene duplication allowing for mutations to accumulate and expand the genome over generations
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