What would be the orientation of the protein across the ER membrane if the gene were mutated such that the third transmembrane domain coded for hydrophilic amino acids

hi i’m going crazy about going tomorrow and i’ll tell you what i’m doing and i wanna is a way ya

multiplying and dividing the two decimals and the eqations by the same number of the overalls

"it built up in the atmosphere"

i think thats it, idk, i tried looking for this exact q& a for grad. and idk if i got this question right or sorry if im wrong