6. The activated form of the drug omeprazole used to treat peptic ulcer disease prevents
acid secretion by forming a covalent bond
with the H2,K2 ATPase thereby inhibiting
the entryme's transport capabilities
Analyus of the drug treated protein
demonstrated that an internal cysteine
residue was involved in the covalent
Interaction with the drug Further analysis
indicated that the bond was not susceptible
to acid or base catalyzed hydrolysis. Based
on this information, one would expect the
drug to contain which of the following
functional groups that would be critical for
its inhibitory action?
A) A carboxylic acid
B) A free primary amino group
C] An imidazole group
DJ A reactive sulfhydryl group
E) A phosphate group