Mutations in genes that encode tRNAs can create tRNAs that recognize stop codons. Because stop codons are sometimes called nonsense codons, these types of mutations that affect tRNAs are called nonsense suppressors. For example, a normal tRNAGly has an anticodon sequence CCU that recognizes a glycine codon in mRNA (GGA) and inserts a glycine during translation. However, a mutation in the gene that encodes tRNAGly could change the anticodon to ACU. This mutant tRNAGly would still carry glycine, but it would recognize the stop codon UGA.
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Would this mutation affect attenuation of the trp operon?
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