How does the cancer cell remove the anti-cancer drug? The drug diffuses into the extracellular space by osmosis. The drug diffuses into the extracellular space by osmosis. The drug diffuses out of the cell through the transport protein. The drug diffuses out of the cell through the transport protein. The cell uses energy to remove the drug by active transport. The cell uses energy to remove the drug by active transport. The cell generates energy as it removes the drug by passive transport.