Sickle-cell anemia is caused by a mutation that changes the second nucleotide of the codon from GAG to GUG. This results in a change of the amino acid from glutamic acid to valine. If the mutation affected the third nucleotide of the codon and changed GAG to GAU then the amino acid would change from a glutamic acid to aspartic acid. Would you predict this change to have the same effect

This change would be predicted to have less effect compared to the change of the amino acid from glutamic acid to valine.

Explanation:

A conservative mutation is a type of mutation that leads to the replacement of one amino acid by another with similar properties. Both glutamic acid and aspartic acid are similar in size and biochemical properties. These amino acids are acidic dicarboxylic acids (i.e., they contain two carboxyl groups or ―COOH). The side chains of both glutamic acid and aspartic acid are similar, with the exception that glutamic acid contains one additional methylene group in its side chain.

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