Down syndrome is a genetic disorder caused by the presence of an extra chromosome number 21 in the body cells of humans. This extra chromosome most
likely is a result of

the menstrual cycle – higher tier. negative feedback mechanisms affect the production of hormones in the menstrual cycle. oestrogen also stimulates the release of lh (luteinising hormone) from the pituitary gland, which in turn controls the production of progesterone.

loss of sensation to pressure and touch

the dorsal column–medial lemniscus pathway (dcml) (also known as the posterior column-medial lemniscus pathway (pcml)) is a sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception (position) from the skin and joints.

i believe your answer would be phagocytosis