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Explain why the phenotypes associated with the human FXN gene can be studied in a mouse cell. Unlike skeletal muscle cells, heart muscle cells cannot rely on fermentation for long. Explain the inability of heart muscle cells to function using only fermentation for metabolism. ATP acts as a negative feedback regulator of phosphofructokinase, one of the enzymes in glycolysis. Predict the eventual effect of ATP on pyruvate production in heart cells that express excess amounts of the normal frataxin.
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Explain why the phenotypes associated with the human FXN gene can be studied in a mouse cell. Unlike...
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