How many nucleotides are required for a 459-amino acid polypeptide? Just enter the

number.

The correct answer is 1377.

Explanation:

Peptides and proteins are made in the process of Translation. For this to happen, a molecule of mRNA containing a nucleotide sequence is read by a structure called ribosome. Each group of three nucleotides from the mRNA form a codon, and each codon has an anticodon in the tRNA molecule that will ultimately code for a specific amino acid (except for stop codons -when they appear in the sequence, translation stops-). Taking all of this into consideration, if 3 nucleotides lead to 1 amino acid, to have a 459-amino acid polypeptide it would require 1377 nucleotides (without counting the 3 nucleotides from the stop codon).