Athletes with mono are typically held out of all physical activity for a period of after diagnosis.

They are usually held out for a period of FOUR TO SIX WEEKS after diagnosis. Splenomegaly is an infectious disease that corrupt the spleen and the enlarged spleen usually persist even after all the symptoms have disappeared. Because of this, athletes should not resume active exercise too soon. Generally, the shortest period after which it is okay to resume active exercise is four weeks after all the symptoms have gone.