The initiation of transcription requires that enhancers bind to mastering biology

The initiation of transcription requires that enhancers bind to promoter DNA. Promoters are usually located on sites where transcription starts - 5’ region. Technically, enhancers, general transcription factors and RNA polymerase should bind to promoter DNA to initiate the process of transcription — so RNA polymerase can create a transcription bubble to separate the double strand of the DNA.

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