What would have to happen to the dna for pkd-1 for the protein to emerge defective

As a small change in a person's dna can cause a genetic disorder

Someone me with this: a mineral' is determined by its actomic structure.

1. seamount a raised footwall block between normal fault creates this 2. syncline break between rocks where a hanging wall rises relative to a footwall 3. hot spring on rolling hills, this a dip between hills 4. volcanic neck created when a block with hanging walls slips down between normal faults 5. caldera underwater volcano that never reaches above sea level 6. horst natural hot water on earth's surface containing many minerals 7. graben underwater volcano whose top is eroded flat by waves 8. crater less than a mile in diameter; looks like a bowl at the top of a volcano 9. guyot magma that filled the central vent that remains after the volcano has eroded 10. reverse fault over 1 mile in diameter; looks like a bowl over a volcano