Which of the following describes the fundamental difference between prokaryotic and eukaryotic cells?

Prokaryotic cells do not have a true nucleus or membrane-bound organelles.

Explanation: The most fundamental difference between prokaryotic and eukaryotic cells is the presence or absence of a true nucleus and membrane-bound organelles, such as mitochondria and chloroplasts. Eukaryotes have them; prokaryotes do not. In fact, the name prokaryote means "before a nucleus".

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