( )-Jatrophone, a natural product isolated from the flowering plant Jatropha gossypiifolia, is known to function as a tumor inhibitor and has been used to treat cancerous growths. As part of the first total synthesis4 of ( )-jatrophone, compound 1 was prepared and then treated with compound 2 in the presence of Pd(PPh3)4 to give compound 3. Draw the structure of compound 3.

Imagine that certain laws of physics could be ignored and you were able to travel vast distances in moments. now imagine that you traveled to an earth-like planet located light-years away that is known to support life. think about what you’ve learned in this unit and make an argument for what you think would be the dominant type of life form on this planet. consider whether a notochord is required for an organism to manipulate its environment and become a dominant creature.

The kidney filters potentially toxic substances in the blood, and thus “clears” the blood of those substances. this clearance function is dependent upon and proportional to the diffusion gradient of the substance across filtering capillaries, i. e. if the concentration of the substance is doubled, twice as much will be cleared from each ml of blood that is filtered. suppose that the body produces a constant amount of a substance x per unit of time. the kidneys eliminate substance x at a rate directly proportional to the concentration of the substance and the volume of blood cleared each minute (c): elimination = c × [x], where [x] is the steady-state concentration of substance x. imagine an individual with an initial concentration of x equal to [x]0 who develops kidney disease. her baseline clearance c0 drops to one half of the original (½c0). what is the new steady state concentration of x? (for simplicity, assume that substance x is 100% filtered by the kidney).

Moving down the ramp from 6 meters to