Heparin, a highly negatively charged glycosaminoglycan, is used clinically as an anticoagulant. It acts by binding several plasma proteins, including antithrombin III, an inhibitor of blood clotting. The 1:1 binding of heparin to antithrombin III seems to cause a conformational change in the protein that greatly increases its ability to inhibit clotting. What amino acid residues of antithrombin III are likely to interact with heparin

Positively charged amino acids

Explanation:

Heparin is an acid polysaccharide that has a strong negative charge due to the sulfate groups on its glucosamine residues. This negative charge confers to heparin anticoagulant activity. The negatively charged groups in the heparin molecule can interact with positively charged (basic) residues, such as arginine (Arg) and lysine (Lys) of plasma proteins. For example, it has been shown that lysine amino acid residues of antithrombin III may be involved in the binding with heparin.

the apgar score is 6

here are the 5 factors that are observed when calculating the apgar index:

skin color

blue everywhere - 0 points

white on the ends and pink on the body - 1 point

all pink - 2 points

heartbeat

absent - 0 points

slow - 1 point

fast - 2 points

reflexes

no answer: 0 points

responds to stimulations: 1 point

cries and coughs: 2 points

muscle tone

soft: 0 point

some bending or stretching: 1 point

active movements: 2 points

breathing

absent: 0 points

weak or irregular: 1 point

good and your baby is crying: 2 points

it is estimated that children whose score is between 8 and 10 are in perfect health and need only routine care. a score between 5 and 7 is representative of a fair condition. often this means that the child has suffered during delivery and probably needs with breathing. as a first step, your doctor will carefully rub the skin of your baby or give him oxygen with a mask.