The spindle fibres start appearing from stage of karyokinesis. 1. prophase
2. methaphas
3.araphase
4. telophasa​

methaphas is the answer

[A] Prophase.

In metaphase, the microtubules pull the sister chromatids and align them in the equatorial plane. In anaphase, the sister chromatids get separated due to the pulling by the spindle fibers. Therefore, the stage of karyokinesis, the spindle fibres start appearing is prophase.

there are mainly three domains in biological classification namely; archaea, bacteria, and eukarya.

archaea includes all the prokaryotic cells which are characterized by their lipid membranes. they have branched hydrocarbon which is attached to glycerol through an ether linkage.

bacteria includes all the prokaryotic cells, the cell membrane of which are made up of the unbranched fatty acid chain. in addition, they are attached to glycerol through an ester bond.

eukarya includes all the eukaryotic cells, that is, the cells contain a nucleus and other membrane-bound cell organelles.

they can be autotrophic as well as heterotrophic, unicellular as well as multicellular

they include kingdoms like protista, plantae, animalia, fungi et cetera.

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