The concept of induced fit refers to the fact that a. Substrate binding may induce a conformational change in the enzyme, which them brings catalytic groups into proper orientation. b. When enzymes bind substrates, the substrates are bought into proximity to make a chemical reaction favorable. c. When a substrate binds to an enzyme, the enzyme induces a loss of water from the substrate. d. When a substrate binds to an enzyme, free energy is released due to non-covalent interactions.

Option A, Substrate binding may induce a conformational change in the enzyme, which them brings catalytic groups into proper orientation.

Explanation:

Induced fit concept refers to introduction of continuous change of enzyme conformation on substrate binding. This change in the shape of enzyme either inhibit or enhance the activity of enzyme. This makes the enzyme catalytic and hence lower the activation energy thereby increasing rate of reaction.

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