If LAL (limulus amebocyte lysate) turns into a gel when exposed to a sample, it means the sample is contaminated with gram-negative bacteria. True or false

The statement is TRUE.

Explanation:

Gram negative bacteria is a type of bacteria that possesses, from the interior to the exterior, a cytoplasmic membrane, a thin peptidoglycan layer, and an outer membrane containing lipopolysaccharide. The lipid portion of the lipopolysaccharide complex of the outer layer acts as an ENDOTOXIN.

The endotoxin of the gram negative bacteria can be detected in research or biomedical laboratories through a technique called LIMULUS AMEBOCYTE LYSATE test.

The test procedure follows a principle that the endotoxin of these gram negative bacteria are capable of forming gel clots (coagulation) of blood cell (amoebocytes) lysates of the Limulus polyphemus crab.

Therefore, If LAL (limulus amebocyte lysate) turns into a gel when exposed to a sample, it

means the sample is contaminated with endotoxins of gram-negative bacteria.

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