Most animal cells exhibit anchorage dependence, which means that in order to divide, Most animal cells exhibit anchorage dependence, which means that in order to divide, nonkinetochore microtubules from opposite poles must overlap and be attached by motor proteins. cell-surface phospholipids must be attached to those of adjoining cells. all chromosomes must be attached to spindle microtubules. cells must be attached to a substrate or extracellular matrix of a tissue.