Which of the following describes a frameshift mutation? A)Insertion or deletion of a group of nucleotides that is a multiple of three
B)Insertion or deletion of nucleotides that results in a premature stop codon
C)Insertion or deletion of a group of nucleotides that is not a multiple of three
D)Substitution of one nucleotide for another

The statement that best describes the frameshift mutation is insertion or deletion of a group of nucleotides that is not a multiple of three (option C).

Explanation:

Frameshift mutation occurs when nucleotides are inserted or lost in a sequence of bases, altering the reading frame and the way nitrogenous bases are grouped together.

The sequence of nucleotides in DNA determines the mRNA nucleotide sequence, on which amino acid synthesis depends. This sequence is read in threes, and the gain or loss of nucleotides, not multiples of three, causes the normal reading to be altered.

A change in the reading frame can produce an amino acid that does not correspond to the structure of a protein, or the coding of a STOP codon,  which interrupts the synthesis of a protein and leaves it incomplete.