Which mutation is the most harmful?
Why?

The main role of dna in the  cell is the long-term storage of information. it is often compared to a blueprint, since it contains the instructions to construct other components of the  cell, such as  proteins  and rna molecules.the main function of rna is to carry information of amino acid sequence from the genes to where  proteins  are assembled on  ribosomes  in the  cytoplasm. mark brainliest, my work is good.

Mitochondria produce atp, a high energy compound. atp is used for all sorts of enzyme-mediated reactions, such as making proteins/nucleotides/etc, certain compounds cross the cell membrane, muscles move, etc.  without this source of energy, a cell will die. it will not be able to repair itself, defend against pathogens, etc.