Explain Why is there a net gain of onlý two ATP molecules in the glycolysis of one six-carbon glucose?

While 4 molecules of ATP are produced in total, 2 were used to convert glucose to the reactive fructose-1,6-bisphosphate

Thus, 4 ATP- 2ATP= 2ATP

Explanation:

In the cytoplasm, cellular respiration starts, where glucose is broken down for energy production. in the presence of oxygen, energy is produced through aerobic respiration, while in an oxygen-deprived environment, anaerobic respiration can be carried out.

Glucose is a relatively stable molecule, thus in order for the pyruvate-producing reaction to occur, the molecule undergoes phosphorylation through the addition of high energy phosphate groups to drive the reaction forward.

Pyruvate is generated through glycolysis in the cytoplasm-it is oxidized to form acetyl CoA in aeroboc respration also used in fermentation (anaerobic respiration) as an electron acceptor.

the endomembrane system is a series of compartments that work together to package, label, and ship proteins and molecules. in your cells, the endomembrane system is made up of both the endoplasmic reticulum and the golgi apparatus. these compartments are folds of membranes that form tubes and sacs in your cells.