Mitochondria are often described as the powerhouses of the cell. Genetic disorders can result when mitochondrial mutations occur. For example, a condition called Kearns-Sayre syndrome is caused by deletions in the mitochondrial DNA. This genetic disorder causes weakness of the muscles and other symptoms because the mitochondria are not able to provide sufficient energy to the cells. The diagram shows the possible phenotypes of children from parents who have the disease.
Diagram showing cytoplasmic inheritance
How is Kearns-Sayre syndrome inherited? Select the best explanation.
A. Genetic disorders caused by mitochondrial mutations are examples of cytoplasmic inheritance. Only mothers transmit mitochondrial genetic disorders to their children. The male gametes have little cytoplasm. They do not contribute mitochondria to the embryos.
B. Genetic disorders caused by mitochondrial mutations are examples of polygenic inheritance, because they are transmitted from fathers to children. Mitochondria are provided by both parents in the cytoplasm of the gametes.
C. Mitochondrial genetic disorders are inherited as a dominant trait in the egg cell DNA, causing disease in the child.
D. Mitochondrial genetic disorders are inherited as a dominant trait in the sperm cell DNA, causing disease in the child.
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